Purity Of Bisphenol S
Since bisphenol analogs are structurally and chemically similar to BPA, many researchers have recently been looking into the effects of these BPA alternatives. The study of BPA itself is relatively new, with the scientific community only reaching consensus that BPA is an EDC in 2013. The study of bisphenol analogs that have replaced BPA is an even newer field of study. For example, a review study from 2015 investigated all in vitro and in vivo studies of both BPS and BPF in the scientific literature up to that point and found only 32 articles. Only seven of those articles were in vivo studies. A current database search of only BPS reveals several hundred studies that compare the bisphenol analog to BPA, and other BPA alternatives. The pathophysiological articles are mainly reporting correlations with cancer, metabolic disorders, obesity, DNA damage, liver damage, neural damage, oxidative stress, and most often endocrine effects and reproductive effects. The vast majority of these articles have been published between 2016 and 2019, with China and Europe taking the lead in this particular field of research. These publications also use many different types of tissue and cell cultures from mice to humans for in vitro studies. For in vivo studies, animal models from zebrafish to swine have been used, as well as clinical studies correlating bisphenol analogs with reproductive effects, mainly.
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